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Lavie, medical director of cardiac rehabilitation at Ochsner Heart and Vascular Institute in New Orleans, said, "This study provides some degree of support that Avandia is probably not adversely affecting cardiovascular health to any major degree. 8 -- The debate over the heart-attack risks posed by the type 2 diabetes drug Avandia has taken another twist, with a new study questioning the results of the research that kick-started the controversy. Three other studies (mean duration 41 months; 14,067 total patients), comparing Avandia to some other approved oral antidiabetic agents or placebo, have not confirmed or excluded this risk. In the case of Avandia, researchers focused on the durability of the patients' blood sugar control ("glycemic durability"), even though blood sugar control is "a relatively poor surrogate for cardiovascular outcomes in type 2 diabetes," Rosen said. 12 issue of the Journal of the American Medical Association, as does another study, this one finding that Actos (pioglitazone), a diabetes drug in the same class as Avandia, actually reduces the risk of heart attack, stroke and death, even while it increases the risk for serious heart failure.
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